Immunoglobulin light chain amyloidosis

Summary Immunoglobulin light chain (AL) amyloidosis is a rare and underdiagnosed life-threatening systemic disease, primarily caused by insoluble depositions of misfolded monoclonal chains. The paraprotein originates from small clonal B‑cell or plasma cell population. If left undetected the can induce number complications based on organ damage. most dangerous dysfunction emerges cardiac involvement. Thus, patients overall survival depends early detection. Establishing correct diagnosis clear characterization amyloid-forming protein, staging, risk assessment treatment are crucial depend highly experienced interdisciplinary, multiprofessional team.